2016 Iowa State Football Season Schedule - Cyclones
2016 Iowa State University Football Season Schedule
| Date | Time | Opponent | Results |
| Sept. 3 | 7 p.m. | Northern Iowa | |
| Sept. 10 | 6:30 p.m. | at Iowa | |
| Sept. 17 | 11 a.m. | at TCU | |
| Sept. 24 | 11 a.m. | San Jose | |
| Oct. 1 | TBA | Baylor | |
| Oct. 8 | TBA | at Oklahoma State | |
| Oct. 15 | TBA | at Texas Longhorns | |
| Oct. 29 | TBA | Kansas State | |
| Nov. 3 | 6:30 p.m. | Oklahoma | |
| Nov. 12 | TBA | at Kansas | |
| Nov. 19 | TBA | Texas Tech | |
| Nov. 26 | TBA | West Virginia |