2015 Iowa State Football Season Schedule - Cyclones
2015 Iowa State University Football Season Schedule
| Date | Time | Opponent | Results |
| Sept. 5 | Northern Iowa | W 31-7 | |
| Sept. 12 | Iowa | L 31-17 | |
| Sept. 19 | at Toledo | L 30-23 |
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| Oct. 3 | Kansas | W 38-13 | |
| Oct. 10 | at Texas Tech | L 66-31 | |
| Oct. 17 | TCU | L 45-21 | |
| Oct. 24 | at Baylor | L 45-27 | |
| Oct. 31 | Texas (Homecoming) | W 24-0 | |
| Nov. 7 | at Oklahoma | L 52-16 | |
| Nov. 14 | Oklahoma State | L 35-13 | |
| Nov. 21 | at Kansas State | L 38-35 | |
| Nov. 28 | at West Virginia | L 30-6 |